What does RTS,S stand for?

RTS,S is a scientific name given to this malaria vaccine candidate and represents its composition. The 'R' stands for the central repeat region of Plasmodium (P.) falciparum circumsporozoite protein (CSP); the 'T' for the T-cell epitopes of the CSP; and the 'S' for hepatitis B surface antigen (HBsAg).

What is the meaning of RTS,S?

RTS,S/AS01 (RTS,S) is a vaccine that acts against Plasmodium falciparum, the deadliest malaria parasite globally and the most prevalent in Africa. The vaccine significantly reduces malaria and life-threatening severe malaria in children. On 6 October 2021, WHO recommended widespread use of the RTS,S malaria vaccine.

What type of vaccine is RTS,S?

RTS,S/AS01 (trade name Mosquirix) is a recombinant protein-based malaria vaccine. In October 2021, the vaccine was endorsed by the World Health Organization (WHO) for "broad use" in children, making it the first malaria vaccine candidate, and first vaccine to address parasitic infection, to receive this recommendation.

How does RTS,S vaccine work?

RTS,S Development RTS,S aims to trigger the immune system to defend against the first stages when the Plasmodium falciparum malaria parasite enters the human host's bloodstream through a mosquito bite and infects liver cells.

How does RTS,S AS01 vaccine work?

The RTS,S/AS01 malaria vaccine targets the circumsporozoite protein, inducing antibodies associated with the prevention of Plasmodium falciparum infection.

What is the name of world’s first malaria vaccine?

A malaria vaccine is a vaccine that is used to prevent malaria. The only approved vaccine, as of 2021, is RTS,S, known by the brand name Mosquirix. It requires four injections.

What kind of vaccine is malaria vaccine?

What do we know about the vaccine? Mosquirix is a “subunit” vaccine. This means it only contains a small part of the malaria parasite, which is produced as a synthetic protein. This protein is coupled with an “adjuvant”, a molecule designed to stimulate a strong immune response.

When was RTS,S developed?

1987 RTS,S was created in 1987 by scientists working in GSK laboratories. In early 2001, GSK and PATH—with support from the Bill & Melinda Gates Foundation—entered into a partnership to develop the vaccine for infants and young children living in malaria endemic regions in sub-Saharan Africa.

How long does the malaria vaccine last?

It is set to be given in four doses, the first three given monthly and the last dose two years later to boost immunity against repeat infections.

What is the name of the world’s first malaria vaccine?

A malaria vaccine is a vaccine that is used to prevent malaria. The only approved vaccine, as of 2021, is RTS,S, known by the brand name Mosquirix….Malaria vaccine.