Who invented malaria drug?

The discovery of a potent antimalarial treatment by Youyou Tu of China, awarded the Nobel Prize in Medicine, is “one of the greatest examples of the century” of the translation of scientific discovery, according to malaria expert Dyann Wirth of Harvard T.H. Chan School of Public Health.The discovery of a potent antimalarial treatment by Youyou Tu of China, awarded the Nobel Prize in Medicine, is “one of the greatest examples of the century” of the translation of scientific discovery, according to malaria expert Dyann Wirth of Harvard T.H. Chan School of Public Health.Oct 5, 2015

When was malaria medicine invented?

In 1820, two French chemists isolated quinine from the cinchona bark and quinine became a treatment of reference for intermittent fever throughout the world. Quinine remains an important and effective treatment for malaria today, despite sporadic observations of quinine resistance.

What was the first medicine for malaria?

The first pharmaceutical used to treat malaria, quinine, was derived from the tree bark of Cinchona calisaya [5]. Quinine synthesis was first attempted in 1856 by William Henry Perkins, but synthesis was not successful until 1944.

Who invented chloroquine?

Hans Andersag worked for Bayer IG Farbenindustrie in Elberfeld, Germany, where he discovered chloroquine (resochin) in 1934 (3). Other scientists associated with Bayer's drug development program evaluated the new compound's safety in animals and humans and considered it too toxic for clinical advancement (6).

Who invented quinine pill for malaria?

In 1820, quinine was extracted from the bark, isolated and named by Pierre Joseph Pelletier and Joseph Caventou. Purified quinine then replaced the bark as the standard treatment for malaria [5]. Quinine and other cinchona alkaloids including quinidine, cinchonine and cinchonidine are all effective against malaria.

How was chloroquine made?

Chloroquine, 7-chloro-4-(4-diethylamino-1-methylbutylamino)-quinoline (37.1. 3), is made by reacting 4,7-dichloroquinoline (37.1. 1.1) with 4-diethylamino-1-methylbutylamine (37.1. 1.2) at 180 °C [1–3].

Where did malaria came from?

The malaria parasites of humans are thought to have evolved in tropical Africa from 2.5 million to 30 million years ago (P. vivax, P. ovale, and P. malariae are among the oldest of the group).

What plant does chloroquine come from?

The cinchona tree is native to Peru. Quinine was the treatment of choice until the 1940s when other drugs, with fewer side effects, replaced it. One of those drugs was chloroquine, which was discovered in 1934.

What is the origin of quinine?

Quinine was first isolated in 1820 from the bark of a cinchona tree, which is native to Peru, and its molecular formula was determined by Strecker in 1854. The class of chemical compounds to which it belongs is thus called the cinchona alkaloids.

What is the brand name of chloroquine?

Chloroquine